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Image Search Results
Journal: PLOS Biology
Article Title: Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period
doi: 10.1371/journal.pbio.3003158
Figure Lengend Snippet: (A) Description of the animal model. Created in BioRender. Bouret, S. (2025) https://BioRender.com/d5iyc5j . (B–E) Representative images and quantification of (B, D) POMC and (C, E) AgRP fibers innervating the (B, C) paraventricular nucleus (PVH) and (D, E) dorsomedial nucleus (DMH) of adult wild-type mice injected with saline (control) or an oxytocin receptor antagonist (L-368,899, OTRA) neonatally ( n = 8−5 animals per group). (F, G) Representative images and quantification of OT (PS38+) neurons and fibers innervating the (F) PVH and (G) lateral hypothalamic area (LHA), respectively, in adult mice injected with saline (control) or an oxytocin receptor antagonist (L-368,899, OTRA) neonatally ( n = 7−6 animals per group). Data are presented as means + SEM. ** P < 0.01. Scale bar 200 μm. The data underlying this Figure can be found in .
Article Snippet: Mice were injected intraperitoneally twice daily with the
Techniques: Animal Model, Injection, Saline, Control
Journal: PLOS Biology
Article Title: Oxytocin neurons drive melanocortin circuit maturation via vesicle release during a neonatal critical period
doi: 10.1371/journal.pbio.3003158
Figure Lengend Snippet: (A) Body weight, (B) body composition, (C) cumulative and (D) average food intake, (E) 24 h and (F) average respiratory exchange ratio, (G) average ambulatory activity, (H) 24 h and (I) average energy expenditure, (J) average Z rearing, (K) fasting glycemia, (L) glucose tolerance test (GTT) and (M) area under the GTT curve in adult male mice injected with saline (control) or an oxytocin receptor antagonist (L-368,899, OTRA) neonatally ( n = 6 animals per group). Data are presented as means ± SEM. * P < 0.05, ** P < 0.01. The data underlying this Figure can be found in .
Article Snippet: Mice were injected intraperitoneally twice daily with the
Techniques: Activity Assay, Injection, Saline, Control